The epithelial cells in megaloblastic anaemias.

The present position of the treatment of megaloblastic anaemias.

A distinction must be drawn between megaloblastic and macrocytic anaemias. Not all macrocytic anaemias are megaloblastic and not all megaloblastic anaemias are macrocytic. The term macrocytosis refers to the size of red blood cells in the peripheral blood. The mean cell volume of packed red blood cells (haematocrit) may be greater than normal, or the diameters of a proportion of red blood cells...

Changes in buccal cells in the anaemias.

Morphological abnormalities of the haemopoietic cells in pernicious anaemia have been well known for many years, but it is only recently that attention has been drawn to abnormalities in the epithelial cells. Graham and Rheault (1954) studied the buccal epithelial cells in gastric washings and showed that there was general enlargement of the cytoplasm and of the nucleus, the presence of some ce...

Carbohydrates and sulphur-containing compounds in the anaemic buccal epithelium.

Mucosal biopsies from the inside of the cheek show epithelial atrophy, glycogen depletion, and an occasional increase in sulphydryl content in both iron-deficiency and megaloblastic anaemias. These changes are the same in the two types of anaemia but are more marked in the latter group.

The megaloblastic anaemias.

The absorption of vitamin B12 in the megaloblastic anaemias.